Clinical Pharmacology Shared Resource
Director, Lionel D. Lewis, M.B. B.Ch., M.D.
Clinical Pharmacologist
Professor of Medicine and Pharmacology/Toxicology
Contact Information
Location: Borwell Research Building, Room 322W
Telephone: 603-650-7811/8685
E-Mail: Lionel.Lewis@Dartmouth.edu
Personnel
Research Faculty
- Hong-Kee Lee, Ph.D.
- Gregory J. Tsongalis, PhD
Lab Manager and Senior Research Assistant
- Bernard Beaulieu, MS., (Tel: 603-650-7649)
Research Assistant
- Jean Bean, B.S., Research Assistant
- Brian Highhouse, R.N., Research Nurse
- Kate Mackay, R.N., Research Nurse
Research Pharmacist:
- Robert Enos, RPh
Mission
The primary function of the Clinical Pharmacology Shared Resource (CPSR) is to support NCCC investigators in the design, analysis, and interpretation of clinical pharmacology objectives in preclinical and clinical studies, including chemoprevention and epidemiological studies.
Facilities
The Clinical Pharmacology Shared Resource operates in well equipped laboratories in the Borwell Research Building (322W and adjacent rooms). In addition, to the biorepository function of our resource we also have bioanalytical hardware and computer hardware and state-of-the-art commercial software programs for application to individual and population-based pharmacokinetic and pharmacodynamic modeling, and modeling drug in vitro and in vivo combination drug effects.
Equipment
- Eight 25 cu ft, low-temperature (-70oC) freezers,
- One 13 cu ft -35 oC freezer
- Electronic bar coding sample management system:
- Two (1 Waters and 1 Varian) HPLC systems; the Varian system is controlled by a state-of the-art automated computerized system
- HPLC Accessory UV and fluorescence detectors and integrator/plotters
- Minimass Waters LC-MS/MS quadropole system
- MagnaPure LC DNA Extractor and ABI 700 PCR
- Third Wave Invader Assay on a Tecan Fluorimeter
- Nanogen Molecular Biology Workstation
- Computers with state-of-the-art statistical pharmacokinetic /pharmacodynamic modeling software.
Services Provided
- Biorepository, sample collection/receipt, processing, logging, storage and mail out
- Consultation re study design for pharmacokinetic and pharmacodynamic study endpoints
- Analyte measurement in biological samples by HPLC and LC-MS/MS
- Pharmacokinetic and pharmacodynamic data modeling and analysis
- Pharmacogenetic assays and expertise
- Research nursing resource
Charges
Charges for the biorepository function and for development and application of various analytical assays or PK modeling are negotiated with the PI, depending on the volume of samples, difficulty of the assay, project, etc.
