Two Cancer Center Researchers Named AAAS Fellows

Duane Compton and Jason Moore named to prestigious scientific society

Two members of Norris Cotton Cancer Center's research team have been selected as 2011 fellows by the American Association for the Advancement of Science (AAAS), the world's largest general scientific society and the publisher of the journal Science.

Focus article photo

Duane Compton, PhD

Duane Compton, PhD, and Jason Moore, PhD, are among 539 new fellows recognized by AAAS this year for their distinguished efforts to advance science.

The Mechanisms of Cancer

Duane Compton, PhD, a member of the Cancer Center's Cancer Mechanisms Research Program, and senior associate dean for research and professor of biochemistry at Dartmouth Medical School (DMS), focuses on the mechanisms of chromosome segregation during cell division in human cells and the effects of chromosomal instability in human tumor cells. Chromosome instability complicates treatment by helping cancer tumors evade the effects of chemotherapeutic drugs. Compton and his DMS research team identified two proteins that play an important role in regulating chromosome segregation. By manipulating levels of these proteins, they facilitated correct chromosome division—the first time anyone has successfully suppressed chromosome instability.

Identifying Cancer Biomarkers
Photo: Jason Moore, PhD

Jason Moore, PhD

Jason Moore, PhD, a member of the Cancer Epidemiology and Chemoprevention Research Program, is the Third Century Professor as well as professor of genetics and of community and family medicine at DMS. He also serves as director of the Institute for Quantitative Biomedical Sciences at DMS. Moore's research seeks to develop, evaluate, and apply novel computational methods and software for identifying genetic and genomic biomarkers associated with human health and disease. The focus is on methods that embrace, rather than ignore, the complexity of the genotype-to-phenotype mapping relationship due to phenomena such as epistasis. His work centers on improving the prediction, prevention, and treatment of common human diseases such as cancers, cardiovascular diseases, and psychiatric diseases through the development, evaluation, and application of statistical and computational methods for genetic, genomic, and proteomic analysis. He serves as managing editor for the publication, Frontiers in Biosciences, and is a founding member of the editorial board for Cancer Informatics.

In this year's group of Dartmouth College and DMS AAAS new fellows, Compton and Moore were joined by Russell Hughes, PhD, the Frank R. Mori Professor of Chemistry at the College; Lee Lynd, the Paul E. and Joan H. Queneau Distinguished Professor in Environmental Engineering Design at Thayer School of Engineering and an adjunct professor of biological sciences at the College; and George O'Toole, professor of microbiology and immunology at DMS.

Cancer Center members who were named AAAS fellows in previous years include Michael Sporn, MD, a member of the Cancer Epidemiology and Chemoprevention Research Program, and Harold Sox, MD, a member of the Cancer Control Research Program.

The American Association for the Advancement of Science, founded in 1848, is a nonprofit organization that includes 262 affiliated societies and science academies and serves 10 million people. Its mission is to "advance science and serve society" through initiatives in science policy, international programs and science education, including its website devoted to science news, EurekAlert!.

December 09, 2011