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carfilzomib

Pronunciation: kar FILZ oh mib

Brand: Kyprolis

What is the most important information I should know about carfilzomib?

Multum calldoc

Carfilzomib can affect your heart or lungs. Call your doctor at once if you have chest pain, pounding heartbeats, shortness of breath (even with mild exertion or while lying down), swelling of your hands or feet, pounding heartbeats or fluttering in your chest, feeling like you might pass out, wheezing, gasping for breath, cough with foamy mucus, or blue colored appearance of your lips and skin.

What is carfilzomib?

Carfilzomib is a cancer medication that interferes with the growth and spread of cancer cells in the body.

Carfilzomib is used to treat multiple myeloma.

Carfilzomib is usually given after at least two other cancer medications have been tried without success.

Carfilzomib may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before receiving carfilzomib?

Multum donot

You should not use carfilzomib if you are allergic to it.

To make sure carfilzomib is safe for you, tell your doctor if you have:

  • kidney disease (or if you are on dialysis);
  • heart disease; or
  • liver disease, or abnormal liver function tests.
Multum nopreg

FDA pregnancy category D. Do not use carfilzomib if you are pregnant. It could harm the unborn baby. Use effective birth control to avoid pregnancy during your treatment with carfilzomib. Follow your doctor's instructions about how long to prevent pregnancy after your treatment ends.

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It is not known whether carfilzomib passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

How is carfilzomib given?

Carfilzomib is injected into a vein through an IV. A healthcare provider will give you this injection.

Carfilzomib is given in a 28-day treatment cycle. You will receive an injection only on certain days of this cycle.

Your doctor will determine how many treatment cycles you should receive.

Multum water

You may be given medication to prevent certain side effects while you are receiving carfilzomib. Drink plenty of liquids before and after your carfilzomib injections.

Multum calldoc

Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while receiving this medication.

Multum emt

You may need frequent medical tests to be sure this medication is not causing harmful effects. Your cancer treatments may be delayed based on the results of these tests.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while receiving carfilzomib?

Avoid coming into contact with your body fluids (including urine, feces, vomit, semen, vaginal fluid). This medicine can pass into body fluids. Patients or caregivers should wear rubber gloves while cleaning up body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.

Body fluids should not be handled by a woman who is pregnant or who may become pregnant. Use condoms during sexual activity to avoid exposure to body fluids.

Multum dizzy

This medication may cause you to feel light-headed or short of breath. Be careful if you drive or do anything that requires you to be alert.

What are the possible side effects of carfilzomib?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects may occur within 24 hours after the injection. Tell your caregiver right away if you feel dizzy, weak, nauseated, light-headed, feverish, sweaty, or if you have joint or muscle pain, a headache, chest tightness, back pain, trouble breathing, or swelling in your face.

Multum calldoc

Call your doctor at once if you have:

  • shortness of breath (even with mild exertion or while lying down), swelling of your hands or feet;
  • anxiety, sweating, pale skin, wheezing, gasping for breath, cough with foamy mucus, fast or uneven heart rate;
  • chest pain spreading to the arm or jaw, sweating, general ill feeling;
  • pounding heartbeats or fluttering in your chest, feeling like you might pass out;
  • blue colored appearance of your lips and skin;
  • fever, swollen gums, painful mouth sores, pain when swallowing, skin sores, cold or flu symptoms, cough, trouble breathing;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • slow heart rate, weak pulse, confusion, lower back pain, blood in your urine;
  • little or no urinating;
  • numbness or tingly feeling around your mouth or in your hands and feet;
  • muscle weakness, tightness, or contraction, overactive reflexes; or
  • upper stomach pain, loss of appetite, dark urine, jaundice (yellowing of the skin or eyes).

Common side effects may include:

  • nausea;
  • diarrhea; or
  • feeling tired.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect carfilzomib?

Other drugs may interact with carfilzomib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Where can I get more information?

Your pharmacist can provide more information about carfilzomib.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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