A Randomized, Multicenter, Open-Label, Phase III Trial Comparing Trastuzumab plus Pertuzumab plus a Taxane Following Anthracyclines versus Trastuzumab Emtansine plus Pertuzumab Following Anthracyclines as Adjuvant Therapy in Patients with Operable HER2-Positive Primary Breast Cancer
This two-arm, randomized, open-label, multicenter study will evaluate the efficacy and
safety of Kadcyla (trastuzumab emtansine, also known as T-DM1) in combination with Perjeta
(pertuzumab) versus Herceptin (trastuzumab) in combination with Perjeta and a taxane as
adjuvant therapy in patients with HER2-positive primary invasive breast cancer. Following
surgery and anthracycline-based chemotherapy, patients will receive either Kadcyla 3.6 mg/kg
and Perjeta 420 mg intravenously (iv) every three weeks or Herceptin 6 mg/kg iv every three
weeks in combination with Perjeta and a taxane. Anticipated time on HER2 targeted study
treatment is up to 1 year. Enrollment is complete for this study and a total of 1846
patients have been randomized.
View more details from ClinicalTrials.gov.
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