STEAM (Sequencing Triplet with Avastin and Maintenance): FOLFOXIRI/Bevacizumab Regimens (concurrent and Sequential) vs. FOLFOX/Bevacizumab in First-Line Metastatic Colorectal Cancer
This randomized, open-label, multicenter study will evaluate the efficacy and safety of
FOLFOXIRI/Avastin (bevacizumab) regimens (concurrent and sequential) versus FOLFOX/Avastin
in first-line in patients with metastatic colorectal cancer. Patients will be randomized to
receive Avastin 5 mg/kg intravenously every 2 weeks with either concurrent or sequential
FOLFOXIRI or with FOLFOX for 4 to 6 months of induction therapy, followed by maintenance
therapy with Avastin plus either leucovorin/5-fluorouracil or capecitabine until disease
progression occurs. After disease progression, patients will receive treatment with a
fluoropyrimidine-based chemotherapy plus Avastin.
View more details from ClinicalTrials.gov.
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