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Victor R. Ambros, Ph.D.

Professor of Genetics

Contact Information

Phone: 603-650-1939
Fax:603-650-1188
Labphone:603-650-1940
Email Address: Victor.Ambros@Dartmouth.edu

Laboratory Website:http://chronic.dartmouth.edu/VRA/ambroslab.html

Postal Address

Dr. Victor Ambros
Vail 609 HB 7400
Dartmouth Medical School
Hanover NH 03755

Education

S.B., Biology, MIT 1975
Ph.D., Biology, MIT, 1979
Postdoctoral Fellow, MIT 1979-83

Program Membership

Cancer Mechanisms Research Program

Department Membership

Genetics

Graduate Training Program Affiliation

Molecular and Cellular Biology

Biography

Selected Publications

Lee, R. C. and Ambros, V. (2001)An extensive class of small RNAs in Caenorhabditis elegans. Science Oct 26; 294:862-864

Sokol, N. S. and Ambros, V.(2005) Mesodermally expressed DrosophilamicroRNA-1 is regulated by Twist and isrequired in muscles during larval growth. Genes and Development 19: 2343-2354

Abbott,A. L., Alvarez-Saavedra, E., Miska, E. A., Lau, N. C., Bartel, D. P., Horvitz, H. R. andAmbros, V. (2005). The let-7 MicroRNAFamily Members mir-48, mir-84, and mir-241 FunctionTogether to Regulate Developmental Timing in Caenorhabditis elegans. DevelopmentalCell, Vol. 9, 1–12, September, 2005

Awards and Honors

Newcomb Cleveland Prize (shared)2002 American Association for the Advancement of Science for an outstanding paper published in Science

Lewis S. Rosenstiel Award for Distinguished Work in Basic Medical Research Brandeis University, 2005

Genetics Society of America Medal 2006, for outstanding contributions in the field of Genetics in the past 15 years

Research Interests

MicroRNAs and Genes Controlling Developmental Timing in Animals
The temporal control of cell division, differentiation, and morphogenesis during metazoan development depends fundamentally on the control of differential gene activity, influenced by a combination of cell-extrinsic and cell-intrinsic temporal cues. We use the C. elegans and Drosophila model systems to explore the genetic and molecular mechanisms underlying the temporal control of events during animal development, and in particular the developmental roles of microRNAs and related regulatory pathways.

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