Sergei Tevosian, Ph.D. | Cancer Research | Norris Cotton Cancer Center

Sergei Tevosian, Ph.D.
Associate Professor of Genetics

Contact Information

Phone: 603-650-1013

Fax:

Labphone:

Email Address: Sergei.G.Tevosian@Dartmouth.edu

Website: http://www.dartmouth.edu/~mcb/faculty/tevosian.html

Laboratory Website : http://www.dartmouth.edu/~genetics/sergei/

Postal Address

Dr. Sergei Tevosian

Remsen 706A

Dartmouth Medical School

Hanover NH 03755

Education

Tufts University, Ph.D. 1997

Program Membership

Cancer Mechanisms Research Program

Department Membership

Genetics

Graduate Training Program Affiliation

Molecular and Cellular Biology

Biography

Selected Publications

Jacobsen CM, Mannisto S, Porter-Tinge S, Genova E, Parviainen H, Heikinheimo M, Adameyko II, Tevosian SG, Wilson DB. GATA-4:FOG interactions regulate gastric epithelial development in the mouse. Dev Dyn. 2005 Oct;234(2):355-62.

Ackerman KG, Herron BJ, Vargas SO, Huang H, Tevosian SG, Kochilas L, Rao C, Pober BR, Babiuk RP, Epstein JA, Greer JJ, Beier DR. Fog2 is required for normal diaphragm and lung development in mice and humans. PLoS Genet. 2005 Jul;1(1):58-65.

Adameyko II, Mudry RE, Houston-Cummings NR, Veselov AP, Gregorio CC, Tevosian SG. Expression and regulation of mouse SERDIN1, a highly conserved cardiac-specific leucine-rich repeat protein. Dev Dyn. 2005 Jun;233(2):540-52.

Manuylov NL, Fujiwara Y, Adameyko II, Poulat F, Tevosian SG. The regulation of Sox9 gene expression by the GATA4/FOG2 transcriptional complex in dominant XX sex reversal mouse models. Dev Biol. 2007 Jul 15;307(2):356-67.

Manuylov NL, Smagulova FO, Tevosian SG. Fog2 excision in mice leads to premature mammary gland involution and reduced Esr1 gene expression. Oncogene. 2007 Aug 9;26(36):5204-13.

Research / Lab Interests

1. GATA4/FOG2 complex function in the mammary gland development
We are interested in understanding the role for the GATA4/FOG2 transcription complex in the maintenance of epithelial cell differentiation in the mammary gland and in performing a protective role in breast cancer. We have recently confirmed that Fog2 is required for the normal expression of two genes (Esr1 and Foxa1) that are correlated with a favorable outcome in breast cancer. We are collaborating with James DiRenzo to determine the mechanism of GATA4/FOG2 function in immortalized human mammary epithelial cells.

2. Activation and Function of DKK1 in Ovarian Cancer
In this project we aim to explore the role for WNTs, FOG2 and DKK1 in ovarian cancer. Although expression of DKK1 was observed previously in ovarian cancer cell lines and ovarian surface epithelium (OSE), the effects of Wnt signaling and activated DKK1 expression on normal OSE has not been explored. We also plan to address the potential of DKK1 to serve as a marker of pre-neoplastic changes in OSE. Because small molecule inhibitors of Wnt/b-catenin signaling are under development, it is imperative to evaluate the normal function for the Wnt pathway that could be adversely affected by such drugs in the OSE. Finally, it is essential to understand the effect of DKK1 over-expression in the ovarian tumors on normal OSE cells.

Grants, Honors, Invited Lectures

Ad hoc for a ACS Study section on Development January 2003