Mary Jo Mulligan-Kehoe, Ph.D.
Research Associate Professor of Surgery
| Education |
| Ph.D. Biochemistry Catholic University of Louvain, Brussels,
Belgium |
| M.S. Molecular Biology George Mason University, Fairfax, Virginia |
| B.S. Biology Northern Michigan University, Marquette, MI |
| Program Membership: |
| Angiogenesis Research Center |
| Norris Cotton Cancer Center |
| Department Membership |
| Surgery |
| Biography: |
| Selected Publications: |
Drinane M, Walsh J, Mollmark J, Simons M, Mulligan-Kehoe MJ. The
Anti-angiogenic activity of rPAI-123 inhibits fibroblast growth factor-2
functions. J. Biological Chemistry 281: 33336-33344, 2006.
|
Research / Lab Interests:
Delivery of a Novel Angiogenesis Inhibitor to Sites of Neo-angiogenesis in
Breast and Brain Tumors
We discovered that a truncated PAI-1 protein has significant anti-angiogenic
activity. Now, in collaboration with Michael Simons and Mark Israel and with
support of NCCC developmental funds, we are developing a system that will
enable us to deliver the angiogenesis inhibitor to sites of angiogenesis in
tumors. The proposed delivery system will be endothelial precursor cells
expressing on their surface an antibody to an angiogenic marker. These
studies utilize extensive microCT and ultrasound microscopy imaging to
quantify tumor volume and tumor vessel density. MicroPET imaging is used to
verify delivery to the tumor. Thus, we aim to detect, diagnose and possibly
treat early stage breast and brain malignancies.
|
| Grants, Honors, Invited Lectures: |
| Co-Investigator NIH/ National Heart, Lung and Blood Institute
Principal Investigator NIH/ National Heart, Lung and Blood Institute
Principal Investigator Young Investigator Development Award |
| 1997 US Patent # 5,702,892: Mulligan-Kehoe MJ. Phage-display
of immunoglobulin heavy-chain libraries. |
| 1998 US Patent #08/897,040: Mulligan-Kehoe MJ. Phage-display
of immunoglobulin heavy-chain libraries for identification of inhibitors
of intracellular constituents. |
| 2000 Australia Patent #715757: Mulligan-Kehoe MJ. Phage display
of immunoglobulin heavy-chain libraries. |
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