Scott Gerber, Ph.D.
Assistant Professor of Genetics
| Contact Information |
| Phone: (603) 653-3679 |
| Fax: (603) 653-9923 |
| Labphone: (603) 653-6182 |
| Email Address: Scott.Gerber@Dartmouth.edu |
| Website : |
Postal Address |
| Scott Gerber |
Rubin 7th, HB-7937 |
| Hanover, NH 03755 |
Shipping Address |
| Scott Gerber |
| Borwell Dock |
| Lebanon, NH 03756 |
Education |
| AB in Chemistry, Willamette University, 1993 |
| PhD in Analytical Chemistry, University of Washington, 2001 |
Program Membership |
| Cancer Mechanisms Research Program |
Department Membership |
| Genetics |
Biography |
| Dr. Gerber received a BA from Willamette University (1993) and a PhD in Analytic Chemistry from the University of Washington (2001). He was a Research Fellow in the Department of Cell Biology at Harvard Medical School from 2001-2006 before coming to Dartmouth. He directs the Proteomics core of the Molecular Biology and Proteomics Shared Resource. |
Selected Publications |
|
Gerber SA, Kettenback AN, Rush J, Gygi SP; The absolute quantification
strategy: application to phosphorylation profiling of human separase serine
1126. Methods Mol Biol. 2007, 359: 71-86. Hu X, Eszterhas S, Pallazzi N, Bouhassira EE, Fields J, Tanabe O, Gerber SA, Bulger M, Engel JD, Groudine M, Fiering S; Transcriptional interference among the murine {beta}-like globin genes. 2007, 109:2210-6. Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP; A novel probability-based approach for high-throughput protein phosphorylation analysis and site localization. Nature Biotechnology. 2006 In press. Haas W, Faherty BK, Gerber SA, Elias JE, Beausoleil SA, Bakalarski CE, Li X, Villen J, Gygi SP; Optimization and use of peptide mass measurement accuracy in shotgun proteomics. Mol Cell Proteomics. 2006 Jul 5(7): 1326-37. Everley PA, Bakalarski CE, Elias JE, Waghorne CG, Beausoleil SA, Gerber SA, Faherty BK, Zetter BR, Gygi SP; Enhanced analysis of metastatic prostate cancer using stable isotopes and high mass accuracy instrumentation. J Proteome Res. 2006 May 5(5): 1224-31. Dieguez-Acuna FJ, Gerber SA, Kodama, S, Elias JE, Beausoleil SA, Faustman D, Gygi SP; Characterization of mouse spleen cells by subtractive proteomics. Mol Cell Proteomics. 2005 Oct 4(10): 1459-70. Denison C, Rudner AD, Gerber SA, Bakalarski CE, Moazed D, Gygi SP; A proteomic approach to gaining insights into protein sumoylation in yeast, Mol Cell Proteomics. 2005 Mar;4(3):246-54. Ballif B, Roux PP, Gerber SA, MacKeigan JP, Blenis J, Gygi SP; Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors, Proc Natl Acad Science U S A. 2005 Jan 18; 102(3) 667-72. Motamedi MR, Verdel A, Colmenares S, Gerber SA, Gygi SP, Moazed D; Two RNAi complexes, RITS and RDRC, associate together and localize to noncoding centromeric RNAs, Cell. 2004 Dec. 17; 119(6) 789-802. Tanny JC, Kirkpatrick D, Gerber SA, Gygi SP, Moazed D; Budding yeast silencing complexes and regulation of Sir2 activity by protein-protein interactions. Mol Cell Biology. 2004 Aug;24(16):6931-46. Verdel A, Jia S, Gerber SA, Sugiyama T, Gygi SP, Grewal SI, Moazed D; RNAi-mediated targeting of heterochromatin by the RITS complex., Science. 2004, Jan 30;303(5658):672-6. Vrabioiu AM, Gerber SA, Gygi SP, Field CM, Mitchison TM; The majority of Saccharomyces cerevisiae septin complexes do not exchange guanine nucleotides, J Biol Chemistry. 2004, Jan 23;279(4):3111-8. |
Research / Lab Interests |
| Cancer research in the Gerber lab is focused on the application of modern proteomics methods to the early detection and cellular mechanisms of lung cancer. An estimated 160,000 Americans will die from lung cancer in 2007. Overall, only 16% of these patients will survive for 5 years from diagnosis. However, when detected at the earliest stage, the survival rate jumps to 47%. Using a mouse model of lung cancer developed by Ethan Dmitrovsky, we are developing and implementing novel methods in quantitative proteomics to develop biomarkers for the early detection of the disease. Aurora kinase A, an oncogene, has been shown to be highly expressed in as many 80% of non small-cell lung cancers. Overexpressed Aurora A results in centrosome amplification, chromosome instability and aneuploidy, all hallmark features of lung cancer. Importantly, Aurora A kinase activity is essential for these transforming events to occur. We are currently focused on determining the cellular targets of inappropriately expressed Aurora kinase A using methods in quantitative chemical phosphoproteomics as a means to better understand how this kinase contributes to oncogenesis. |
