Steven N. Fiering, Ph.D.
Associate Professor of Microbiology and Immunology and of Genetics
| Contact Information |
| Phone: 603-653-9966 |
| Fax: 603-653-9952 |
| Labphone: |
| Email Address: steven.fiering@dartmouth.edu |
| Website: http://www.dartmouth.edu/~mcb/faculty/fiering.html |
| Laboratory Website : http://www.dartmouth.edu/dms/microbio/faculty/fiering.shtml |
Postal Address |
| Dr. Steven N. Fiering |
| Rubin Bldg. HB 7936 |
| 1 Medical Center Drive |
| Lebanon NH 03756 |
Education |
| Stanford University, Ph.D. 1990 |
| University of Michigan B.Sc. 1975 |
| After postdoctoral work as an NIH research fellow and research associate at the Fred Hutchinson Cancer Research Center, Dr. Fiering joined the faculty of the Department of Microbiology at Dartmouth Medical School in 1997. |
Program Membership |
| Cancer Mechanisms Research Program |
Department Membership |
| Microbiology/Immunology and Genetics Departments |
Graduate Training Program Affiliation |
| Molecular and Cellular Biology |
Biography |
| Dr. Fiering also directs the Dartmouth Transgenic Mouse Facility, a shared resource that is part of the Norris Cotton Cancer Center shared resources. |
Selected PublicationsHu, X., M. Bulger, J.N. Roach, S.K. Eszterhas, E. Olivier, E.E. Bouhassira, M. Groudine, S. Fiering; Promoters of the murine embryonic ß-like globin genes Ey and ßh1 do not compete for interaction with the ß-globin locus control region. Proc. Natl. Acad. Sci. USA 100:1111-5, 2003 Sutter, N.B., D. Scalzo, S. Fiering, M. Groudine, D.I.K. Martin; Chromatin insulation by a transcriptional activator. Proc. Natl. Acad. Sci. USA 100:1105-10, 2003 Rosenbauer, F., K. Wagner, J.L. Kutok, H. Iwasaki, M. LeBeau, Y. Okuno, K. Akashi, S. Fiering, D.G. Tenen;, Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1. Nature Genetics, 36: 624-30, 2004 Kato, KC, S. Martinez, P. Russel, Nurden, A. Nurden, S. Fiering, J. Ware; Genetic deletion of mouse platelet glycoprotein Ibbeta produces a Bernard-Soulier phenotype with increased alpha-granule size. Blood, 104: 2339-44, 2004 Kang, HC, JH Chae , YH Lee, M-A Park, JH Shin, S-H Kim, S-K Ye, YS Cho, S Fiering, CG Kim; Erythroid cell specific a-globin gene regulation by the CP2 transcription factor family. Mol. Cell. Biol., 25:6005-20, 2005 Hu, X, M. Bulger, M.A. Bender, J. Fields, M. Groudine, S. Fiering: Deletion of the core region of 5'HS2 of the mouse ß-globin locus control region reveals a distinct effect in comparison with human ß-globin transgenes. Blood, 107:821-6, 2006 Hu, X, Eszterhas, S, Pallazzi, N, Bouhassira, EE, Fields, J, Tanabe, O, Gerber, SA. Bulger, M, Engel JD, Groudine, M, Fiering, S: Transcriptional Interference among the murine beta-globin genes. Blood, 109:2210-6, 2007. Ma, Y, S. Fiering, C. Black, X. Liu, Z. Yuan, V.A. Memoli, D.J. Robbins, H.A. Bentley, G. J. Tsongalos, E. Dimidenko, S.J. Freemantle, E. Dmitrovsky. Transgenic Cyclin E triggers dysplasia and multiple pulmonary adenocarcinomas. Proc. Natl. Acad. USA, 104:4089-94, 2007 Mabaera, RH, CA Richardson, KJ Johnson, M Hsu, S Fiering, CH Lowrey. Developmental and differentiation-specific patterns of human gamma and beta-globin promoter DNA methylation. Blood 110, 1343-52, 2007 Hsu, Y.M., R. Mabaera, C.H. Lowrey, D.I.K. Martin, S. Fiering. CpG hypomethylation in large domain encompassing the embryonic beta-like globin genes in primitive erythrocytes. Mol. Cell. Biol., 27:5047-54, 2007 |
Research / Lab InterestsOur primary interest is epigenetic regulation of mammalian transcription in development and in carcinogenesis. Working with Chris Lowrey we have been investigating the developmental changes in chromatin structure during differentiation of cells from precursors into fully differentiated red cells. Our methylation studies were accelerated by the Molecular Biology shared resource. As part of those studies we have worked with the Transgenic shared resource to generate mice with a series of mutations in the beta-globin locus and with Scott Gerber, we were able to identify a novel beta-like globin protein produced in these mice. A recent collaboration with Ethan Dmitrovsky utilized the Transgenic Facility and generated an excellent new transgenic mouse model of lung cancer by expression of cyclin E in the lungs. In collaboration with Mardi Crane and with support of NCCC developmental funds, we have established a new facility to expose rodents to tobacco smoke. We are now collaborating with Crane and Dmitrovsky to expose the cyclin E transgenic mice to tobacco smoke and investigate how this influences the pathology and molecular changes of the lung cancers that develop. The pathology changes will be assayed with the assistance of the Pathology Research Service and the molecular changes will be assayed with the help of the Microarray and Bioinformatics shared resources. |
Grants, Honors, Invited Lectures |
| 1995-97 Scholars Award, American Society of Hematology |
| 1995-2000 Burroughs-Wellcome Career Development Award |
| 1999 and 2000 Ad hoc reviewer, NCI Shared Resource Grants |
