Duane A. Compton, Ph.D.
Professor of Biochemistry
Director, Cancer Mechanisms Research Program
| Contact Information |
| Phone: 603-650-1990 |
| Fax: |
| Labphone: |
| Email Address: Duane.Compton@Dartmouth.edu |
| Website: http://www.dartmouth.edu/~mcb/faculty/compton.html |
| Laboratory Website : http://www.dartmouth.edu/~biochem/compton/ |
Postal Address |
| Dr. Duane A. Compton |
| HB 7200 |
| Dartmouth Medical School |
| Hanover NH 03755 |
Education |
| Ph.D., University of Texas Health Sciences Center, Houston, TX 1988 |
| B.S., University of Oklahoma, Norman OK 1984 |
| Research Fellow, Department of Biological Chemistry, Johns Hopkins University School of Medicine 1989-1993 |
Program Membership |
| Cancer Mechanisms Research Program |
Department Membership |
| Biochemistry |
Graduate Training Program Affiliation |
| Molecular and Cellular Biology |
Biography |
Selected Publications |
Ota, J., Yamashita, Y., Okawa, K., Kisanuki, H., Fijiwara, S., Ishikawa, M., Choi, Y.L., Ueno, S., Ohki, R., Koinuma, K., Wada, T., Compton, D., Kadoya, T., and Mano, H.: Proteomic analysis of hematopoietic stem cell-like fractions in leukemic disorders. Oncogene 22:5720-5728. (2003) Levesque, A.A., Howard, L., and Compton, D.A.: A functional relationship between NuMA and Kid is involved in both spindle organization and chromosome alignment in vertebrate cells. Mol. Biol. Cell 14:3541-3552. (2003) Simerly, C., Dominko, T., Navara, C., Payne, C., Capuano, S., Gosman, G., Chong, K.-Y., Takahashi, D., Chace, C., Compton, D., Hewitson, L., and Schatten, G.: Molecular correlates of primate nuclear transfer failures. Science 300: 297 (2003). Khodjakov, A., Copenagle, L., Gordon, M.B., Compton, D.A., and Kapoor, T.M.: Minus-end capture of preformed kinetochore fibers contributes to spindle morphogenesis J. Cell Biol. 160:671-683 (2003). Kisurina-Evgenieva, O., Mack, G., Du, Q., Macara, I., Khodjakov, A., and Compton, D.A.: Multiple mechanisms regulate NuMA dynamics at spindle poles. J. Cell Sci. 117:6391-6400 (2004) Ganem, N., and Compton, D.A.: The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK. J. Cell Biol. 166:473-478 (2004) Einarson, M.B., Cukierman, E., Compton, D.A., and Golemis, E.A.: Human enhancer of invasion-cluster, a coiled-coil protein required for passage through mitosis. Mol. Cell Biol. 24:3957-3971 (2004) Chakravarty, A., Howard, L., and Compton, D.A.: A mechanistic model for the organization of microtubule asters by motor and non-motor proteins in a mammalian mitotic extract. Mol. Biol. Cell 15:2116-2132. (2004) Ganem, N.J., Upton, K., and Compton, D.A.: Efficient mitosis in human cells lacking polewards microtubule flux. Curr. Biol. 15:1827-1832 (2005) Compton, D.A.: Mitosis: PARty time in the spindle. Current Biol. 15:R178-179 (2005) Compton, D.A.: Mitosis: Disorderly conduct at kinetochores. Curr. Biol. 16:R494-R496. (2006). Ganem, N.J, and Compton, D.A.: Functional roles of poleward microtubule flux during mitosis. Cell Cycle 5:481-485. (2006) Compton, D.A.: Chromosomes walk the line. Nature Cell Biol. 8:308-310. (2006) Manning, A.L., Ganem, N.J., Bakhoum, S., Wagenbach, M., Wordeman, L., and Compton, D.A.: The kinesin-13 proteins Kif2a, Kif2b and Kif2c/MCAK have distinct roles during mitosis in human cells. Mol. Biol. Cell 18: 2970-2979 (2007). Manning, A.L., and Compton, D.A.: Mechanisms of spindle-pole organization are influenced by kinetochore activity in mammalian cells. Curr. Biol. 17: 260-265 (2007). Myers, L.C. and Compton, D.A.: Mitosis: Springtime for chromatin. Curr. Biol. 17:R460-R462 (2007). |
Research / Lab Interests |
Our lab uses biochemical and cell biological tools to determine the mechanisms of chromosome segregation during cell division. The projects include biochemical methods to identify and characterize proteins responsible for proper assembly of the bipolar mitotic spindle. Also, we combine biochemical and cell biological techniques to identify molecules responsible for ensuring the high fidelity of chromosome segregation during mitosis. Finally, with the use of NCCC shared resources, we are examining the mechanisms of chromosome mis-segregation leading to aneuploidy in tumor cells. |
Grants, Honors, Invited Lectures |
