Gross, T., Siepmann, A., Sutrm, D., Windgassen, M., Scarcelli, J.J., Seedorf, M., Cole, C.N., and Krebber, H. (2007) The DEAD-box RNA-helicase Dbp5 functions in translation termination. Science. 315:646-649.
Scarcelli, J.J., Hodge, C.A., and Cole, C.N. 2007. The yeast integral membrane protein Apq12 potentially links membrane dynamics to assembly of nuclear pore complexes. J. Cell Biol., 178: 799-812.
Research / Lab Interests
The Cole lab works on mRNA export, nuclear pore complex biogenesis and microRNAs in breast cancer. Transport of macromolecules through nuclear pores is a key step during gene expression and one that becomes mis-regulated in some cancers. The localization of proteins, including many transcription factors, is carefully controlled and this regulation can be lost in tumors, leading to permanent residence in the nucleus of a key transcription factor, resulting in expression of genes that would normally not be active. In addition, more than 25 different chromosomal translocations have been identified in tumors that result in the production of chimeric proteins containing part of nuclear pore complex protein fused to another cellular protein, often a homeobox protein. In work supported by NCCC developmental funds, the Cole group collaborated with Gary Schwartz and Wendy Wells to define cell type-specific changes of microRNA expression in breast cancer.
