Dr. Murray Korc's Lab

Murray Korc, M.D. (Murray.Korc@Dartmouth.edu)
Chair, Department of Medicine
Joseph M. Huber Professor of Medicine and
Professor of Pharmacology and Toxicology


Grants

Dysregulation of TGF-beta Actions in Pancreatic Cancer, NCI, RO1 CA-75059, 09/30/97 - 02/28/07.
The overall goals of this project are to assess the role of TGF-betas and their receptors in pancreatic cancer.

EGF Receptors and Pancreatic Cancer, NCI, RO1 CA-40162, 04/01/89-11/30/05.
The overall goals of this project are to study the role of the EGF receptor family in pancreatic cancer, compare the signaling pathways activated by these receptors, and evaluate the effectiveness of dominant-negative EGF receptor constructs and chemical inhibitors that target the EGFR tyrosine kinase to suppress pancreatic cancer cell growth.

Role of Neuropilins in Pancreatic Cancer, NCI, R01 CA-102687, 09/30/03-08/31/08.
The overall goal of this project is to find out whether neuropilins contribute to VEGFR-dependent signaling pathways.

Role of Glypican-1 in Pancreatic Cancer, NCI, R01 CA101306, 04/01/03-03/31/08.
The overall goals of this project is to determine the clinical significance of glypican-1 expression in pancreatic cancer cells in vivo; determine the biological significance of glypican-1 expression in pancreatic cancer cells; investigate the basis for the unique role of glypican-1 in cell growth control.