Wayne State University School of Medicine, Detroit, MI 1962
Internship(s):
Harper University Hospital, Detroit, MI, (Rotating) 1962-63
Residency:
Mayo Graduate School of Medicine, Rochester, MN, (Internal Medicine) 1963-66
Fellowship(s):
Mayo Graduate School of Medicine, Rochester, MN, (Hematology) 1968-69
Biography:
Dr. Zacharski received his BA in 1959 and his MD in 1962, both from Wayne State University. Following an internship at Harper Hospital in Detroit, he completed his residency in internal medicine and a fellowship in hematology at the Mayo Clinic. Since coming to Dartmouth Medical School in 1970, Dr. Zacharski has established and chaired two multi-institutional cancer treatment studies, has maintained an active research and diagnostic coagulation laboratory, and he has published over 200 papers and abstracts in the field of blood coagulation, particularly with reference to malignancy. In addition to his active research, Dr. Zacharski serves as area consultant in blood coagulation for the DHMC, and he maintains a coagulation clinic for the diagnosis and treatment of bleeding and thrombosing disorders.
Research Interests:
Dr. Zacharski's early interest in the mechanism by which cells and tissues initiate coagulation activation led to a focus on the pathophysiology of coagulation activation in malignancy. He has characterized the heterogeneous pathways by which neoplastic cells interaction with host coagulation reactions in most of the common adult tumor types. Evidence from experimental animal systems that showed inhibition of tumor dissemination with anticoagulant treatment led him to perform clinical trials of drugs of this type in human disease. More recently, Dr. Zacharski has turned his attention to studies of oxidant stress that triggers procoagulant and plasminogent activator expression in both neoplastic and normal cell types.
Ornstein DL, Lord K, Yanofsky NN, Cornell CJ, and Zacharski LR. Successful donation and transplantation of multiple organs after fatal poisoning with brodifacoum, a long acting anticoagulant rodenticide: Case report. Transplantation, 67(3):475-478, February 15, 1999.
Zacharski LR and Ornstein DL. Heparin and cancer. Thrombos Haemostas, 80:10-23, 1998.
Zacharski LR, Ornstein DL, Memoli VA, Rousseau SM, and Kisiel W. Expression of the Factor VII activating protease, hepsin, in situ in renal cell carcinoma. Thrombos Haemostas, 79:876-877, 1998.
