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James R. Rigas MD

Contact Information:
Phone: (603) 650-6344
Fax: (603) 650-9496
Email: not given

Institution Affiliations:
Director, Comprehensive Thoracic Oncology Program
Associate Professor of Medicine
Department of: MEDICINE
Section: Hematology/Oncology
Specialty: Medical Oncology
Joined Staff: 1995

Cancer Center Membership:
Molecular Therapeutics Research Program

Clinical Interests:
Thoracic Oncology
Board Certified:
Medical Oncology 1993
Internal Medicine 1988
Degree(s): MD
Medical College of Pennsylvania, Philadelphia, PA 1984

Internship(s):
Dartmouth-Hitchcock Medical Center, Lebanon, NH,
1984 - 85
Residency:
Dartmouth-Hitchcock Medical Center, Lebanon, NH, (Internal Medicine) , Chief Resident 1987-88 1985-87

Fellowship(s):
Memorial Sloan-Kettering Cancer Center, New York, NY, (Medical Oncology) 1988-90

Biography:
Dr. Rigas received his BS in Biology in 1977 from Cornell University and his MD in 1984 from Medical College of Pennsylvania. In 1987, chief medical resident 1988, he completed his residency at the DHMC. In 1990 he completed his oncology fellowship from Memorial Sloan Kettering Medical Center. From 1990 to 1995 he was an Instructor in Medicine at Cornell University Medical College and a Clinical Assistant Attending Physician at Memorial Sloan-Kettering Cancer Center. In 1995 he joined the faculty of the DHMC as Director of the Comprehensive Thoracic Oncology Program.

Research Interests:
Dr. Rigas' main clinical research interest is in thoracic oncology. He has had extensive experience in the development of investigational protocols for the study and treatment of lung cancer.

Selected Publications:

PEER REVIEWED JOURNALS

Rigas JR Taxane-platinum combinations in non-small cell lung cancer: A review. The Oncologist 2004; 9(suppl 2): 16-22.

Dragnev KH, Black CC, Rigas JR The role of docetaxel in resectable stage IIIA non-small cell lung cancer Advances in Lung Cancer 2004; 6(2):3-7.

Rigas JR, Dragnev KH Emerging role of rexinoids in non-small cell lung cancer: Focus on bexarotene. The Oncologist 2005; 10:22-33.

Rigas JR, Dragnev DH, Bubis JA Docetaxel in the treatment of esophageal cancer Seminars Oncol 2005; 32(2 Suppl 4):S39-51.

Dragnev KH, Petty WJ, Ma Y, Rigas JR, Dmitrovsky E Non-classical retinoids and lung carcinogenesis Clin Lung Cancer 2005; 6(4): 237-244.

Dragnev KH, Rigas JR First-line chemotherapy options for patients with advanced non-small cell lung cancer Medscape: Clinical Update 2005; (on-line).

Rigas JR, Dragnev KH Targeted therapy with erlotinib (TarcevaŽ) prolongs survival in non-small cell lung cancer Community Oncology: Community Translations 2005; 2(3):205-9.

Rigas JR Controversies in chemotherapy for patients with advanced non-small cell lung cancer: An expert interview with Dr. James R. Rigas Medscape Hematology-Oncology 2005; 8(2) on-line July 27, 2005.

Rigas JR, Lara, PN Current Perspectives on Treatment Strategies for Stage III Non-small Cell Lung Cancer Lung Cancer 50 SuppL. 2 (2005) S17-S24.

Dragnev KH, Feng Q, Ma Y, Shah SJ, Black C, Memoli V, Nugent N, Rigas JR, Kitareewan K, Freemantle S, Dmitrovsky E Uncovering Novel Targets for Cancer Chemoprevention Recent Results in Cancer Research, 2007; 174: 237-245.

ABSTRACTS

Abrey LE, Wen PY, Govindan R, Reimers HJ, Rigas JR, Robins HI, de Bedout S, O'Connell C, Li X, Johri A Activity of patupilone for the treatment of recurrent or progressive brain metastases in patients (pts) with non-small cell lung cancer (NSCLC): an open-label, multicenter, phase II study. Journal of Clinical Oncology 2007, 25 (S) (abstract).

Ross HJ, Blumenschein G, Dowlati A, Garst J, Shepherd FA, Rigas JR, Smylie M, Hassani H, Berger M, Zaks T A Phase 2 Multicenter Trial Comparing Two Schedules of Lapatinib (LAP) as First or Second Line Monotherapy in Subjects with Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) with either Bronchioloalveolar Carcinoma (BAC) or No Smoking History. Journal of Clinical Oncology 2007, 25 (S) (abstract).

Petty WJ, Voelzke WR, Memoli VA, Dragnev KH, Urbanic J, Rigas JR, Dmitrovsky E Expression of cyclin D3 confers resistance to erlotinib. Journal of Clinical Oncology 2007, 25 (S) (abstract).

Black C, Turk M, Delong P, Dragnev K, Johnstone D, Rigas J; FoxP3 immunostaining patterns in human non-small cell lung cancers. Journal of Clinical Oncology 2007, 25 (S) (abstract).

Rigas JR, Rubin MS, Waples JM, Dragnev KH, Zimmerman DM, Reimer RR, Droder R, Rathmann J, Green NB, Carey M Safety assessment for the combination of docetaxel, carboplatin and thoracic radiotherapy in unresectable stage III non-small cell lung cancer (NSCLC): A report of the first 100 patients treated with chemoradiation on D0410. Journal of Clinical Oncology 2007, 25 (S) (abstract).

Dragnev KH, Rigas JR,DiSalvo WM, Simeone SA, Williams I, Hagey AE, Gordon GB, Dmitrovsky E A phase I trial of ABT-751 and carboplatin in patients with previously treated non-small cell lung cancer (NSCLC). 12th World Conference on Lung Cancer, Lung Cancer, 2007, (abstract).

Rigas JR, Rubin MS, Waples JM, Dragnev KH, Zimmerman DM, Reimer RR, Droder R, Rathmann J, Green NB, Carey M Docetaxel, carboplatin and thoracic radiotherapy in unresectable stage III non-small cell lung cancer (NSCLC): A safety report of the first 100 patients treated with this concurrent chemoradiation as part of a multicenter web-based trial, D0410. 12th World Conference on Lung Cancer, Lung Cancer, 2007, (abstract).

Black C, Turk M, Delong P, Dragnev K, Johnstone D, Rigas JR FoxP3 immunostaining patterns in human non-small cell lung cancers 12th World Conference on Lung Cancer, Lung Cancer, 2007, (abstract).

Abrey LE, Wen PY, Govindan R, Reimers HJ, Rigas JR, Robins HI, de Bedout S, Hennan L,Ko JL, Johri A Treatment of recurrent or progressive brain metastases with patupilone in patients with non-small cell lung cancer (NSCLC): results of a multicenter, open-label phase II study. European Cancer Conference, Barcelona Spain 2007, (abstract).

Freemantle S, Feng Q, Liu X, Black C, Memoli V, William Nugent W, Johnstone DW, Rigas JR, Kitareewan S, Dragnev KH, Dmitrovsky E Uncovering retinoid chemoprevention mechanisms. Diet and Cancer; Susceptibility, Prevention and Therapy, Nottingham UK 2007, (abstract).
  

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