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Contact Information:
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Phone: (603) 650-5747
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Fax: (603) 650-5830 |
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Email: not given
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Institution Affiliations:
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Associate Professor of Medicine (Hematology/Oncology) & of Pharmacology and Toxicology
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Department of: MEDICINE
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Section: Hematology/Oncology
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Specialty: Hematology/Oncology
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Joined Staff: 1993
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Cancer Center Membership:
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Clinical Interests:
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Sickle Cell Disease
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Hematologic Malignancies
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Board Certified:
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Hematology/Oncology
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Hematology 1994
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Internal Medicine 1988
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Boston University School of Medicine, Boston, MA 1985
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New England Medical Center Hospitals, Boston, MA, (Internal Medicine) 1985-87
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National Institutes of Health, Bethesda, MD, (Internal Medicine) 1987-88
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National Institutes of Health, Bethesda, MD, (Hematology) 1988-92
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Dr. Lowrey received his BA in Biochemistry in 1979 from Bowdoin College, his MA in Biochemistry in 1981 from the University of PA, and his M.D. in 1985 from Boston University. Following a residency in internal medicine at the New England Medical Center and NIH, Dr. Lowrey completed a Hem/Onc Fellowship from the Institutes of Health Clinical Center in 1992. In 1993 Dr. Lowrey joined the faculty of the Dartmouth Medical School as a member of the Hematology/BMT Program. In 1996 he became Co-Director of the Hem/Onc Fellowship Program in charge of research.
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Dr. Lowrey's areas of research are: 1) Regulation of chromatin structure and its relation to gene expression; 2) Pharmacologic manipulation of gene expression; 3) Gene therapy of hematologic disease.
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1994-2007 : PI
National Heart, Lung and Blood Institute, RO1 (HL52243) Regulation of Beta-Globin Locus Chromatin Structure
Description: The major goals of this project are to determine the regulatory elements which are responsible for forming the erythroid-specific chromatin structures of the locus and to then apply these elements to the design of new gene therapy vectors.
2003-2007 : PI
National Heart, Lung and Blood Institute, R01 (HL73442) Promoter Chromatin Structure in Fetal Globin Silencing
Description: The major goals of this project are to comprehensively determine the chromatin structural changes which occur at the gamma globin gene promoters in primary human erythroid tissue between the fetal and adult stages of development as the genes go from active to silenced. The molecular mechanisms responsible for these silencing-associated chromatin changes will then be determined.
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Nemeth, MJ and Lowrey, CH. An Erythroid-Specific Chromatin Opening Element Increases Globin Gene Expression from Integrated Retroviral Vectors. (2004) Gene Therapy & Molecular Biology, 8:475-486.
Layon, MJ, McInerney, JM, Ackley, K and Lowrey, CH. The GATA-1 Transcription Factor Directs Erythroid-Specific Chromatin Structure Remodeling and Activates an Erythroid Pattern of Gene Expression in Non-Erythroid Cells. In prep.
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Mailing Address:
Norris Cotton Cancer Center
Dartmouth-Hitchcock Medical Center
One Medical Center Drive
Lebanon, NH 03756
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