| Contact Information: |
| Phone: (603) 650-1667 |
| Fax: (603) 650-4454 |
| Email: not given |
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| Institution Affiliations: |
| Chairman, Pharmacology and Toxicology |
| Andrew G. Wallace Professor of Medicine and Pharmacology |
| Department of: MEDICINE |
| Section: Hematology/Oncology |
| Specialty: Medical Oncology |
| Joined Staff: 1998 |
| Cancer Center Membership: |
| Clinical Interests: |
| Thoracic Oncology |
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| Board Certified: |
| Medical Oncology 1985 |
| Internal Medicine 1983 |
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| Cornell University Medical College, New York, NY 1980 |
| New York Hospital - Memorial Sloan-Kettering Cancer Center, New York, NY. (Internal Medicine). 1980-81. |
| New York Hospital - Memorial Sloan-Kettering Cancer Center, New York, NY, (Internal Medicine) 1981-83 |
| National Cancer Institute, National Institutes of Health, Bethesda, MD, Medical Staff Fellow
1983-86 |
| Molecular Genetics Section-Navy Medical Oncology Branch, Bethesda, MD, (Biotechnology) 1986-87 |
| Dr. Dmitrovsky received his BS in 1976 from Harvard University and his MD from Cornell University in 1980. He completed an Internal Medicine residency in 1983 from New York Hospital - Memorial Sloan Kettering Cancer Center in New York City. He did three years of fellowship at the NCI and in 1987 he completed a one year biotechnology fellowship at the NCI Molecular Genetics Section.
Dr. Dmitrovsky then joined the Memorial Sloan-Kettering Cancer Center as a Clinical Assistant Physician in 1987 and in 1989 became an Assistant Professor. In 1992 he became an Associate Professor of Medicine at Cornell and Head of the Laboratory of Molecular Medicine at the Memorial Sloan-Kettering Cancer Center.
In 1994, Dr. Dmitrovsky became an Associate Member of the Sloan-Kettering in the Institute's Molecular Pharmacology and Therapeutics Program. In 1998, he joined Dartmouth Hitchcock Medical Center as Professor and Chairman of the Department of Pharmacology and Toxicology. He also has a lung cancer clinic in the Section of Hematology/Oncology. |
| Dr. Dmitrovsky's laboratory pursues mechanisms responsible for differentiation and chemoprevention in human tumors by the retinoids, derivitives of Vitamin A. He has built a translational research program focusing on the molecular pharmacological role of retinoids in germ cell tumors, leukemias, lung cancers, and other tumors. |
| Kitareewan S, Pitha-Rowe I, Sekula D, Lowrey CH, Nemeth MJ, Gollub TR, Freemantle SJ, Dmitrovsky E. UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia. Proc. Natl. Acad. Sci. (USA) 99: 3806-3811, 2002. |
| Freemantle S, Spinella M, Dmitrovsky E. Retinoids in cancer therapy and prevention: Promise meets resistance. Oncogene 22:7305-7315, 2003. |
| Dragnev KH, Stover D, and Dmitrovsky E. Prevention of lung cancer. Chest 123: 60s-71s, 2003. |
| Pitha-Rowe I, Hassel BA, and Dmitrovsky, E. Involvement of UBE1L in ISG15 conjugation during retinoid induced differentiation of acute promyelocytic leukemia. J. Biol. Chem. 30:18178-18187, 2004. |
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Mailing Address:
Norris Cotton Cancer Center
Dartmouth-Hitchcock Medical Center
One Medical Center Drive
Lebanon, NH 03756
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