The Role of Magnetic Nanoparticles in Breast Cancer Treatment
April 06, 2014
Norris Cotton Cancer Center Presents Research Findings at AACR
Dartmouth to Share its Plans for Clinical Tests in Humans
In a presentation exploring the promise of magnetic nanoparticle (mNP) hyperthermia in breast cancer treatment, Dartmouth researcher P. Jack Hoopes, DMV, PhD, will review preclinical studies conducted at Norris Cotton Cancer Center and discuss plans for early-phase clinical studies in humans.
This evolving treatment approach involves the injection of nanoparticles into the tumor, which are then activated with magnetic energy. Once activated the nanoparticles produce heat inside the cancer cell. The heat kills the cancer cell with minimal damage to surrounding tissue.
P. Jack Hoopes, DVM, PhD, co-director of Norris Cotton Cancer Center's Nanotechnology Working Group, has led efforts in creating platforms, approaches, and equipment to test mNP in the laboratory and in the exam room at the Dartmouth Center of Nanotechnology Excellence.
Hoopes will review biodistribution studies in mice, nanoparticle heating characterization in vitro and in vivo, efficacy studies in mouse tumor models and spontaneous canine oropharyngeal tumors, studies combining nanoparticle hyperthermia with ionizing radiation and chemotherapy and MRI-based nanoparticle imaging. He we also address planned clinical trials in humans at Dartmouth, including navigating the Institutional Review Board (IRB) and the Food and Drug Administration (FDA) and the services provided by the FDA/NIH's Nanoparticle Characterization Laboratory.
Hoopes presentation is scheduled for Sunday, April 6, 2014, from 2:15 pm – 2:35 pm in Room 31 at the San Diego Convention Center during the AACR annual meeting.
About Norris Cotton Cancer Center at Dartmouth-Hitchcock
Norris Cotton Cancer Center combines advanced cancer research at Dartmouth and the Geisel School of Medicine with patient-centered cancer care provided at Dartmouth-Hitchcock Medical Center, at Dartmouth-Hitchcock regional locations in Manchester, Nashua, and Keene, NH, and St. Johnsbury, VT, and at 12 partner hospitals throughout New Hampshire and Vermont. It is one of 41 centers nationwide to earn the National Cancer Institute's "Comprehensive Cancer Center" designation. Learn more about Norris Cotton Cancer Center research, programs, and clinical trials online at cancer.dartmouth.edu.